Skip to main content

Should You Pick a Skin Booster from a Tier List? — Start With Your Concern Instead

"So which one is right for my skin?" That is the question that tends to follow a skin booster tier list, the kind of chart that lines products up by grade. Yet the same product often sits in a high row on one list and a low row on another. Which list is right? In this article, Dr. Jeong, a board-certified dermatologist at ABLE Dermatology in Seoul, looks at why tier lists disagree, how far head-to-head research between products has actually gone, and how to choose in a different order instead of by rank: your concern → the layer where it starts → what the material does → how it is delivered. It is based on studies checked through October 2026, covers only skin boosters (injections placed shallowly in the skin to improve its quality), and is not written to recommend any particular product.

Summary in Three Lines

  • When the same product earns different grades on different tier lists, it is not because the product is different but because the people grading it used different criteria. How much weight they gave to effect, pain, price, duration and safety history is rarely disclosed, and some lists score the delivery method rather than the product, or mix in treatments that do a different job, such as volumizing injections and skin botox.
  • Head-to-head studies between products are few, each with only a few dozen participants, and they look at different areas, such as around the eyes or the cheeks. Data like these cannot support sorting products into ranked grades. That does not mean skin boosters do not work; it means each product does a different job in the skin.
  • That is why we think a skin booster should be chosen not by product name but in this order: your most bothersome concern → the layer where it starts → what the material does → how it is delivered.

Why Tier Lists Disagree — The Criteria Differ, Not the Products

A skin booster tier list lines products up by grade so they can be taken in at a glance. Put several lists side by side, though, and it is not unusual to find the same product in a high row on one list and a low row on another. Some lists even grade the same product twice, once injected by hand and once combined with needle RF, which amounts to scoring the delivery method rather than the product.

Each List Uses Different Criteria, Weighted Differently

The criteria that lists put forward range widely: effect, pain, price, how long results last, safety history, current trends, even whether the grader would recommend it to family. Yet it is hard to find a list that states in numbers how much weight each criterion carried. One list may drop a product a grade because it hurts, while another treats pain as a sign that the product went in properly, and the same product can move up or down a grade because of its price. A list naturally reflects its maker's experience and priorities, so it can hardly serve as the standard for your own skin.

Treatments That Do Different Jobs End Up on One List

Often the list mixes the very kinds of treatment it ranks: skin boosters, which work on the skin itself, sit on the same chart as volumizing injections and even skin botox. Volumizing injections and skin-quality injections do different jobs, so they were never meant to be lined up in one row and compared. For that reason, this article covers only skin boosters, injections placed shallowly in the skin to improve its quality.

Products that are not approved for injection sometimes appear on the same chart. Exosome products are one example: in 2025, 4 cases were reported in which nodules, granulomatous inflammation and scarring remained after such products were injected into the skin in non-medical settings (Park, 2025).

A Single Grade Cannot Show What a Product Is For

Plain hyaluronic acid injections, known in Korea as mulgwang ("water-glow") injections, have clear uses, such as adding moisture a few days before an important event. A single grade on a chart does not show uses like these. In Dr. Jeong's judgment, a high row on a tier list is high only by the standards of the person who made it, and if it does not match your concern, even a product in a high row may not deliver the change you hoped for.

Head-to-Head Studies Between Products Are Few

Direct Comparison Trials — A Few Dozen Participants, Different Areas

One randomized, double-blind split-face study injected polynucleotides (PN, the ingredient family of Rejuran) around one eye and non-cross-linked hyaluronic acid around the other (Lee et al., 2022). After three sessions two weeks apart in 27 people, the overall improvement scores (VAS and GAIS) did not differ between the two sides. Where the two sides did differ was in some machine-measured values, such as skin roughness and pore volume. In other words, the overall impression was similar, and the differences showed up in a few instrument readings.

A single-blind split-face comparison of two hyaluronic acid injectables, each given three times to one cheek in 24 healthy women, reached a similar conclusion: both sides improved in hydration and elasticity, but there was no significant difference between the products (de Wit et al., 2022).

There is also a systematic review of PN studies, but it included only 9 studies with 219 people in total, and their quality was rated low to moderate (Lampridou et al., 2025).

Collagen-Stimulating Injections — How Far the Skin-Quality Evidence Goes

Collagen-stimulating injections such as Juvelook Skin (PDLLA), Ultracol 100 (PDO) and GOURI (liquid PCL) appear on tier lists often, but studies in people that used them for skin quality are still few.

  • PDLLA — In a 16-person preliminary study of an injectable mixing PDLLA with non-cross-linked HA, given 2 to 3 times at 4-week intervals, fine lines, texture, pigmentation and redness improved, and biopsies from behind the ear showed more collagen and elastic fibers (Seo et al., 2024; no control group). In a 40-person study using a needle-free injection device for 5 sessions, the overall improvement score (GAIS) rose from 1.48 to 2.16 at week 24 (Seo et al., 2026; no control group; a specific device). A frequently cited PDLLA pore study (Wan et al., 2025; a 15-person case series) turns out, on reading its methods, to have applied PDLLA to the skin right after 0.5 mm microneedling. It did not look at the effect of injection alone.
  • PDO — We could not find a clinical study in people that assessed skin quality with Ultracol 100. Collagen formation from PDO injections has been reported at the level of a mouse experiment (Kwon et al., 2019; an animal study co-authored by the manufacturer's research center).
  • Liquid PCL — In a 30-person single-arm study aimed at midface volume, with two sessions given by cannula, improvements in skin quality and volume were reported (Ponzo et al., 2025; product name not stated). That is why it can help when you want a little added volume along with improved texture. Human data that name GOURI amount to a retrospective pilot study of 3 people treated around the eyes (Choe et al., 2026), and we could not find a controlled study of shallow injection for skin quality.

Going by the data available so far, all three materials are at the stage of uncontrolled studies or animal experiments. That does not mean they do not work; it means there are not yet data for comparing or ranking them against each other.

To Sum Up — Why a Ranked Order Is Hard to Build

Direct comparison trials are few, each with roughly 20 to 30 people, and the areas studied vary from around the eyes to the cheeks (Lee et al., 2022; de Wit et al., 2022). Even the Re2O study discussed below, which reported differences between the two sides on several measures, had 20 participants (Lee et al., 2026). Results from the eye area or the cheeks cannot simply be carried over to the whole face, either. We think data like these make it hard to sort products into a few grades and build a ranked order.

That is not to say skin boosters do not work. Each product is simply good at a different job, so choosing what fits your concern matters more than any ranking.

Sorting by What They Do, Not by Rank — Four Kinds of Skin Booster

There are dozens of product names, but grouped by what they do inside the skin, they come down to four kinds. The dermis, where skin boosters go, is a network of collagen and elastic fibers with water filling the spaces in between, and each material does something different to that structure. The grouping below assumes use as a skin booster, placed shallowly in the skin to improve its quality.

Injections That Help the Skin Hold Water — Non-Cross-Linked HA and Skin-Quality Cross-Linked HA

Hyaluronic acid draws in water and holds on to it, so added moisture shows from right after the injection. Non-cross-linked HA, the type used in mulgwang injections, breaks down quickly but is light, while lightly bound (cross-linked) skin-quality HA such as BELOTERO REVIVE is made to stay longer. When you need moisture ahead of an important event, its effect tends to be felt quickly.

Injections That Support Recovery — PN (Rejuran)

This type helps rough, tired skin recover. Its ingredient is made from DNA fragments obtained from salmon, and the proposed mechanism is that it forms a water-holding, mesh-like structure that supports an environment for recovery. A 2026 international expert opinion paper summarizing this, however, itself notes that the evidence is still limited (Rho et al., 2026). It is a material used widely, from texture and fine lines to acne scars.

Injections That Replenish the Base — hADM (Re2O)

This is a dermal matrix material (ADM) made by removing the cells from donated human skin tissue and turning it into a powder, and it works more like filling the thinned dermis with base material itself. It is used when you want to add a sense of density to skin that has become dull and limp as the dermis has thinned.

The skin-quality clinical evidence for Re2O is a single randomized, double-blind split-face study of 20 adults with rough cheeks (Lee et al., 2026). Non-cross-linked HA was injected as the control, and differences between the two sides were reported on several measures, but the differences in hydration and physician-rated scores appeared from week 8, and the difference in pores from week 12. In other words, it cannot be cited as evidence that this material shows results quickly. The same hyaluronic acid was also mixed into the test side, and one of the authors had advised on the product's development. As it is a single 20-person study, long-term results need more time, and CellREDM, another product in the same category, differs in brand and manufacturing process, so we do not carry these results over to it.

At Korea's National Assembly audit of government agencies in October 2026, the need to overhaul the management system for this category of products was raised. Korea's Ministry of Food and Drug Safety (MFDS) replied that it maintains its position that using human tissue for cosmetic purposes is not appropriate, and said it would prepare a management plan within 2026 after a policy study. How differently tier lists rate this category also comes down to how each views its safety history. The regulatory situation is set out separately in our column on ECM skin boosters. While long-term data accumulate, we avoid treating too often or too heavily.

Injections That Get Your Body to Make Collagen — PDLLA, PDO and Liquid PCL

Juvelook Skin (PDLLA), Ultracol 100 (PDO) and GOURI (liquid PCL) belong here. They prompt your body to weave new fibers around the tiny particles injected (GOURI is a liquid). Because they are materials not originally found in skin, they trigger a foreign-body reaction that leads to collagen, which places them in the collagen stimulator family. This article keeps them separate from procedures that place the same ingredients deeper and in larger amounts to add volume, and covers only their use as skin boosters, in small amounts placed shallowly in the skin.

Because your body has to make the fibers, results take time and vary considerably from person to person. Keep in mind, too, that even when used shallowly, the ingredient keeps its properties, so the effect is hard to reverse. We consider them when you want to work on firmness and texture together, even if it takes a little longer.

A Separate Treatment Considered Alongside — Intradermal Botulinum Toxin (Skin Botox)

Rather than a material that fills something, this treatment reduces signals such as oil production and fine muscle activity, so it is not one of the four kinds above. We consider it alongside skin boosters when redness or oiliness is also a concern.

What it does in the skinIngredient (product examples)Main layerWhen changes appearConcerns it suits
Helps the skin hold waterNon-cross-linked HA (mulgwang injections), skin-quality cross-linked HA (BELOTERO REVIVE)DermisFrom right after the injectionInner dryness, dullness, fine texture lines
Supports recoveryPN (Rejuran)DermisGradually, over a series of sessionsFine lines, thin skin, sensitive skin
Replenishes the basehADM (Re2O)DermisIn the study, the hydration difference appeared from week 8 and the pore difference from week 12 (Lee et al., 2026)Thin dermis, texture
Gets your body to make collagenPDLLA (Juvelook Skin), PDO (Ultracol 100), liquid PCL (GOURI)Dermis to just below itOver weeks to monthsTexture, loss of firmness, elasticity-type pores
Separate treatment considered alongsideIntradermal botulinum toxin (skin botox)Dermis (shallow and diluted)—Redness, oiliness

A Map by Concern — What a Single Ranking Cannot Hold

So what should you go by? In a skin quality consensus reached by 10 aesthetic dermatology experts using the Delphi method, there was strong agreement that good skin can be described, across all ethnicities, by four qualities: even tone, an even surface (texture), firmness and glow (Goldie et al., 2021). The same consensus notes that surface problems can start in deeper tissue, so topical care alone may not be enough and several layers may need to be treated together.

Put simply, dryness that feels tight underneath points to water in the dermis, redness points to blood vessels and inflammation, and with pores you need to see whether they come from oil, loss of firmness or inflammation. That is why "Which layer did my concern start in?" has to come before "Which booster is good?" How to choose by tissue condition, such as skin thickness and firmness, is set out separately in our column on choosing a skin booster; here we simply connect each concern with the four jobs above.

Dryness That Feels Tight and Dull

We look first at injections that help the skin hold water (non-cross-linked HA, or skin-quality cross-linked HA such as BELOTERO REVIVE). In a randomized study comparing a cross-linked HA designed for cheek skin texture (VYC-12L) with an untreated control group, the proportion of people whose cheek smoothness improved at 1 month was clearly higher than in the control group. Participants were mostly Western, however, with a median age of 58 (Alexiades et al., 2023; 131 vs 71 people). In a randomized study that gave the same formulation as BELOTERO REVIVE (CPM-HA20G) to 159 people, improved hydration in dry skin was reported for up to 9 months after the last injection, but there was no untreated control group (Kerscher et al., 2021).

If the dryness stings or burns, it may be a barrier problem rather than simply a lack of water, and the whole approach changes.

Red, Sensitive Skin

How to choose a skin booster for sensitive skin is covered at length in our column on sensitive skin and rosacea. In brief, we look first at injections that support recovery (PN), then at hyaluronic acid such as BELOTERO REVIVE, with Re2O as a supporting option if needed, and we hold off on collagen-stimulating injections.

When redness is the main concern, we consider intradermal toxin first. There are two placebo-controlled randomized studies in patients with rosacea, but both are small and short, and this use is off-label (Kim et al., 2019, 24 people; Dağtaş et al., 2025, 30 people). We could not find clinical trials that assessed PN injected into rosacea or sensitive skin, so in the first session we treat only part of the area and check the response first.

Pores

We divide pores into three types by cause. For the oil-driven type, oil control comes first. For the elasticity type, where firmness has declined with age, we look first at energy-based treatments such as needle RF together with collagen-stimulating injections. For the inflammation-related elasticity type, we look first at barrier recovery and Rejuran. Starting with collagen-stimulating injections without sorting out the cause is something we put off. It is also worth remembering that the frequently cited PDLLA pore study used application after microneedling, not injection alone (Wan et al., 2025).

Fine Lines and Thin Skin

We check skin thickness and any previous filler first. We look first at Rejuran or hyaluronic acid, and when the dermis itself has thinned, we also consider injections that replenish the base, such as Re2O. As noted above, the study that directly compared PN and non-cross-linked HA around the eyes found no difference in the overall assessment (Lee et al., 2022).

Loss of Firmness and Mild Sagging

We look together at materials that broadly firm up the layer just below the dermis, such as GOURI, collagen-stimulating injections such as Juvelook Skin and Ultracol 100, and energy-based lifting. If the skin barrier is healthy, energy-based treatment can come first, but if the barrier is damaged or there is inflammation, we move it later.

If the sagging comes from heavy fat or the underlying structure, you may need to set aside the expectation that skin boosters alone will fix it. Filling hollow cheeks is a job for subcutaneous HA such as HILO WAVE, volumizing collagen stimulators or fillers, so it is left out of this map.

First-Time Patients and Those on a Set Budget

We suggest starting with one material for your single most bothersome concern, then widening the plan after seeing how your skin responds. We could not find a comparative trial confirming an advantage for combining several skin boosters from the start over using just one.

ConcernWhat to tell apart firstInjections considered firstWhat we put off
Inner dryness, dullnessSimple lack of water, or a stinging, burning barrier problemInjections that help the skin hold water (non-cross-linked HA, skin-quality cross-linked HA)Intradermal toxin on its own
Red, sensitive skinWhether redness is the main concern; whether there is active inflammationInjections that support recovery (PN) → injections that help hold water (HA) → injections that replenish the base (supporting). If redness is central, intradermal toxin is considered as well; the first session covers only part of the areaCollagen-stimulating injections
PoresOil-driven / age-related elasticity type / inflammation-related elasticity typeOil-driven: oil control. Elasticity type: energy-based treatment and collagen-stimulating injections. Inflammation-related: barrier recovery and injections that support recovery (PN)Starting with collagen-stimulating injections without sorting out the cause
Fine lines, thin skinSkin thickness; any previous fillerInjections that support recovery (PN) or help hold water (HA). If the dermis has thinned, injections that replenish the base—
Loss of firmness, mild saggingWhether sagging comes from heavy fat or structure; barrier conditionCollagen-stimulating injections and energy-based lifting. With a healthy barrier, energy-based treatment can come first; with barrier damage or inflammation, it comes laterExpecting skin boosters alone to fix sagging
First-time patients, set budgetYour single most bothersome concernStart with one material for that concern, check the response, then widen the planCombining several products from the start

The Same Product Can Feel Different Depending on How It Is Delivered

Questions like "Does Rejuran stop working if it is given by cannula?" come up partly because a tier list cannot capture how a product is delivered. A 15-person case series compared three ways of injecting the same formulation as BELOTERO REVIVE (CPM-HA20G): serial puncture (many small needle punctures), a cannula (a blunt-tipped tube) and a multi-needle injector (Booysen and Lin, 2026). The degree of improvement was similar across the three, but pain scores and the amount of bruising differed by method.

In a randomized, double-blind study in which a PDLLA skin booster was injected into the dermis and just below it on the same person's face (21 people), pain scores also differed by injection depth (Yi et al., 2026).

What differed by method in these two studies was pain and bruising, so they offer no basis for ranking delivery methods by effectiveness. They do show clearly, though, that the experience of the same product can change with the delivery method and depth. That is why we choose the delivery method to suit the product and the area, as well as your remaining schedule, pain concerns and medical history.

With Rejuran, we place importance on getting it precisely into the dermis, and we read the small raised bumps at the injection points (emboss) as a sign that it has reached the target layer. In sensitive skin, however, we do not aim for the bumps themselves. Choosing a delivery method by depth, spread and product loss is explained in detail in our column on skin booster delivery.

Intervals and Duration — Why One Number Doesn't Fit

You may often hear claims like "a few sessions a few weeks apart, and it lasts a year," but the research is not that simple. In the study of a cross-linked HA for cheek texture mentioned above, the proportion of people who improved held up to 6 months (Alexiades et al., 2023), and in the study of the same formulation as BELOTERO REVIVE, improved hydration in dry skin was reported for up to 9 months after the last injection (Kerscher et al., 2021). What has been confirmed goes this far: there are studies in which particular measures held for 6 to 9 months with some cross-linked HA products.

That does not mean every skin booster lasts 6 months to a year. Some materials, like Rejuran, are built up over a series of sessions, while others, like GOURI, are topped up once more after seeing how the skin responds. So the accurate answer is that intervals depend on the product, the goal and how your skin responds.

You will often see promotion claiming that a product lasts a long time or brings only benefits, but no product is strong on every count. Dr. Jeong does not recommend simply following a set number of sessions and intervals because "everyone does it that way," without evidence. Instead, he recommends planning like this:

  • Injections that support recovery (such as Rejuran) — built up over several sessions a few weeks apart.
  • Injections that help the skin hold water (such as mulgwang injections) — timed to an important event.
  • Collagen-stimulating injections — topped up while watching the response.

Adjusting as you watch how your skin responds is, in the end, the efficient way to go.

In Summary — Choose in This Order Instead of by Rank

A tier list is its maker's list of priorities, not a prescription for your skin. Instead of going by rank, we suggest choosing in this order:

  1. Pick the one concern that bothers you most right now.
  2. Find the layer where that concern starts.
  3. Choose what to do for that layer: help it hold water, support recovery, replenish the base, or get your body to make collagen.
  4. Decide how it is delivered to fit your remaining schedule, pain concerns and medical history.

When you see us, rather than a product name, it helps to tell us the following. With just this, dozens of products narrow down to the one or two you need now.

  • The one thing that bothers you most
  • Your upcoming schedule, such as events or travel
  • Skin boosters you have had before and how your skin reacted
  • Medications you take now and your medical history

Even if you arrive with a product already in mind, we start by looking together at whether it suits your skin right now. Skin boosters are not a treatment where you need an expensive, well-known product; they do their job when chosen to fit your concern.

Precautions and Limits of the Evidence

This article is general information based on studies and public reports checked up to October 27, 2026, and does not replace individual medical care. Even with the same material and the same method, results can differ with skin thickness, age and skin condition.

After a skin booster treatment, bruising, swelling, redness, injection marks (emboss) and pain can occur, and they usually settle within a few days. Hyaluronic acid products can, rarely, cause vascular complications. Please tell us before treatment about any history of allergies, pregnancy or breastfeeding, anticoagulant use, autoimmune disease and previous fillers.

Rare Nodules and Bruising Worth Knowing About

The small studies of collagen-stimulating materials discussed above did not report severe adverse reactions, and with application after microneedling, mild redness and swelling settled within 48 hours (Wan et al., 2025). Studies of 15 to 40 people, however, cannot tell us how often such problems occur. With collagen stimulator ingredients, rare late-onset nodules and long-lasting bruising have been reported even when they are placed shallowly.

Thin areas call for extra care. There is a case report of granulomatous nodules that developed about 1 month after 3 sessions of PDLLA near the lower eyelid and required surgery (Garlaschi et al., 2026; 1 patient). In Dr. Jeong's judgment, in areas such as the lower eyelid, neither PDLLA nor Re2O should be injected in excessive amounts. With liquid PCL, 7 cases have been reported of bruising that lasted for months after injection under the eyes, at injection points and in the upper arm (Byeon et al., 2026; case series). All of them eventually cleared, but it is good to know before you start that such a course can rarely occur.

In the end, what matters is injecting at the intended layer and in the intended amount. If you can feel something, even weeks after treatment, show us right away. The sooner you do, the easier it is to manage.

Limits of the Evidence

Many of the studies cited are small, short or uncontrolled, and some were sponsored by manufacturers or involved researchers who advised on product development, or device companies. The skin-quality evidence for Ultracol 100 is at the animal-study stage, and we could not find controlled studies of Juvelook Skin or GOURI used for skin quality. What this article says about tier lists draws on a look at the opinions and experience of the people who made them and is not clinical evidence. Using intradermal botulinum toxin for flushing may count as off-label use.

References

  1. Park KY. Adverse Reactions Following Intradermal Injection of Exosome-Based Formulations: A Case Series. J Cosmet Dermatol. 2025;24(10):e70520. doi:10.1111/jocd.70520
  2. Lee YJ, Kim HT, Lee YJ, et al. Comparison of the effects of polynucleotide and hyaluronic acid fillers on periocular rejuvenation: a randomized, double-blind, split-face trial. J Dermatolog Treat. 2022;33(1):254-260. doi:10.1080/09546634.2020.1748857
  3. de Wit A, Siebenga PS, Wijdeveld RW, et al. A split-face comparative performance evaluation of injectable hyaluronic acid-based preparations HCC and CPM-HA20G in healthy females. J Cosmet Dermatol. 2022;21(11):5576-5583. doi:10.1111/jocd.15157
  4. Lampridou S, Bassett S, Cavallini M, et al. The Effectiveness of Polynucleotides in Esthetic Medicine: A Systematic Review. J Cosmet Dermatol. 2025;24(2):e16721. doi:10.1111/jocd.16721
  5. Goldie K, Kerscher M, Fabi SG, et al. Skin Quality - A Holistic 360° View: Consensus Results. Clin Cosmet Investig Dermatol. 2021;14:643-654. doi:10.2147/CCID.S309374
  6. Rho NK, Chilukuri S, Chan G, et al. Expert Perspectives: Evidence-Based Applications of Polynucleotides (PNs) in Aesthetic Medicine and Dermatology. Clin Cosmet Investig Dermatol. 2026;19:557226. doi:10.2147/CCID.S557226
  7. Seo SB, Park H, Jo JY, et al. Skin rejuvenation effect of the combined PDLLA and non cross-linked hyaluronic acid: A preliminary study. J Cosmet Dermatol. 2024;23(3):794-802. doi:10.1111/jocd.16085
  8. Seo SB, Wan J, Yoon SE, et al. The Effective Delivery of Poly(D,L-lactic Acid) (Juvelook) via Needle-Free Injection (CUREJET) for Facial Rejuvenation. Aesthetic Plast Surg. 2026;50(9):3382-3388. doi:10.1007/s00266-025-05434-2
  9. Wan J, Seo SB, Yoon SE, et al. The Efficacy of Combined Microneedling and Topical Poly-d,l-lactic Acid (Juvelook) Application for Facial Pore Reduction and Skin Texture Improvement. Plast Reconstr Surg Glob Open. 2025;13(6):e6838. doi:10.1097/GOX.0000000000006838
  10. Kwon TR, Han SW, Yeo IK, et al. Biostimulatory effects of polydioxanone, poly-d, l lactic acid, and polycaprolactone fillers in mouse model. J Cosmet Dermatol. 2019;18(4):1002-1008. doi:10.1111/jocd.12950
  11. Ponzo M, La Padula S, Lombardi M, et al. Pilot Study: Efficacy and Safety of Polycaprolactone Collagen Stimulator for Middle Third of the Face. Plast Reconstr Surg Glob Open. 2025;13(11):e7285. doi:10.1097/GOX.0000000000007285
  12. Choe SJ, Han JH, Darmawan I, et al. Periorbital Structural and Functional Modulation Following Liquid-Type Polycaprolactone Treatment: A Pilot Study. J Clin Med. 2026;15(11):4303. doi:10.3390/jcm15114303
  13. Alexiades M, Palm MD, Kaufman-Janette J, et al. A Randomized, Multicenter, Evaluator-blind Study to Evaluate the Safety and Effectiveness of VYC-12L Treatment for Skin Quality Improvements. Dermatol Surg. 2023;49(7):682-688. doi:10.1097/DSS.0000000000003802
  14. Kerscher M, Prager W, Fischer TC, et al. Facial Skin Revitalization with Cohesive Polydensified Matrix-HA20G: Results from a Randomized Multicenter Clinical Study. Plast Reconstr Surg Glob Open. 2021;9(12):e3973. doi:10.1097/GOX.0000000000003973
  15. Kim MJ, Kim JH, Cheon HI, et al. Assessment of Skin Physiology Change and Safety After Intradermal Injections With Botulinum Toxin: A Randomized, Double-Blind, Placebo-Controlled, Split-Face Pilot Study in Rosacea Patients With Facial Erythema. Dermatol Surg. 2019;45(9):1155-1162. doi:10.1097/DSS.0000000000001819
  16. Dağtaş BB, Erdem O, Güneç Tİ, et al. Effects of Botulinum Toxin Type A Treatment on Clinical and Biophysical Parameters in Patients With Erythematotelangiectatic Rosacea: A Prospective, Randomized, Controlled, Double-Blind Study. Dermatol Surg. 2025;51(5):515-521. doi:10.1097/DSS.0000000000004528
  17. Booysen K, Lin F. Facial Skin Revitalization With CPM-HA20G (Hyaluronic Acid + Glycerol): A Comparative Case Series Using Three Delivery Techniques With Ultrasound Confirmation. J Cosmet Dermatol. 2026;25(1):e70660. doi:10.1111/jocd.70660
  18. Yi K, Rosellini I, Lau KH, et al. Comparative Pain Assessment of Intradermal Versus Subdermal Skin Booster Injections Using PDLLA: A Randomized, Double-Blinded Split-Injection Study. Aesthetic Plast Surg. 2026;50(11):4212-4217. doi:10.1007/s00266-025-05596-z
  19. Lee YI, Chau NH, Nguyen NH, et al. Injectable Particulated Human Acellular Dermal Matrix Booster for Skin Restoration: An Integrated Randomized, Split-Face, Double-Blinded Clinical Trial and Preclinical Study. Int J Mol Sci. 2026;27(5):2193. doi:10.3390/ijms27052193
  20. Garlaschi A, Colombo G, Dotto A. Complex Surgical Management of PDLLA-Induced Lower Eyelid Granulomas. J Craniofac Surg. 2026 (Epub ahead of print, Apr 27). doi:10.1097/SCS.0000000000012811
  21. Byeon H, Baek H, Vachiramon V, et al. A Case Series of Rare Long-Term Bruising Following Injection of Liquid-Form Polycaprolactone: Mechanisms and Therapeutic Insights. Clin Cosmet Investig Dermatol. 2026;19:571602. doi:10.2147/CCID.S571602

This column is adapted from Dr. Jeong's blog post (2026-10-28, in Korean). Read the original (Korean)

From Consultation Through Treatment

A board-certified dermatologist examines you directly, identifies which layer the cause sits in, sets the device and the parameters, and then carries out the procedure as the same physician. This is not a structure in which a consultant sells the treatment.

The number of sessions, the intervals, the maintenance point and the cost are agreed together before the first session.

Frequently Asked Questions

GOURI shows up on tier lists a lot. Who is it suited to?
That is hard to answer with a grade. By ingredient, GOURI is a liquid PCL collagen stimulator, and used as a skin booster it broadly firms up the layer just below the dermis, which tends to suit an overall loss of firmness. It is good to know that long-lasting bruising has rarely been reported. If pores, texture or a thin dermis is your main concern, a different injection may come first.
Can I alternate Rejuran and Juvelook Skin every 2 weeks?
Rejuran supports recovery and Juvelook Skin gets your body to make collagen, so they do different jobs in the skin. First decide whether you are stacking both on the same concern or giving each one a different concern. We could not find a comparative trial confirming an advantage for alternating them over using just one. Intervals are set by the product, the goal and your skin's response, and if your skin tends to become sensitive, the extra stimulation of overlapping treatments can become a burden.
Re2O came up at Korea's National Assembly audit. Is it all right to have it?
Re2O is a dermal matrix material (ADM) derived from human tissue. What was discussed at the October 2026 audit was overhauling the management system for this category of products; it does not mean that a problem with the product itself was confirmed. Korea's Ministry of Food and Drug Safety does, however, maintain that using human tissue for cosmetic purposes is not appropriate, and the efficacy evidence is still a single small study, so there are no long-term data yet. It is a material used to add density to skin that has become limp as the dermis thinned, and while long-term data accumulate, we avoid treating too often or too heavily.
Can Juvelook Skin or Ultracol 100 cause nodules too?
Rarely, but it is possible. There are no reliable data yet on how often this happens when they are placed shallowly for skin quality, and data that include use for volume show cases that appeared late. If you notice a lump you can feel some weeks after treatment, do not wait; show it to the clinic that treated you right away.
I have a salmon allergy. Can I have Rejuran?
Because the PN raw material comes from salmon, be sure to tell us about any allergy history at your consultation. That said, we have not found case reports of a salmon allergy reaction actually occurring after a PN injection. If you are pregnant or breastfeeding, take blood-thinning medication, have an autoimmune disease or have had fillers before, please tell us about that as well. What needs checking differs by product, so we go through it item by item together at your consultation.

Related Articles

Choosing a Skin Booster Tissue Condition, Not Product Type

When Skinbooster Fails: Finding the Real Cause

Skin Boosters and Collagen Stimulators — Does the Material Work, or Does Your Tissue?

View All Columns
EventsAnnouncements
BookQuick reservation
WhatsAppBusiness Chat
Instagram@ableclinic_official
X@mukderma
DirectionsSongpa, Seoul