Rejuran atopic dermatitis skin regeneration in Seoul Songpa

Rejuran's Regeneration Mechanism

Rejuran (PN, Polynucleotide) is a polynucleotide complex that recognizes cellular damage signals and promotes skin regeneration. Unlike marketing claims of 'DNA repair,' it actually works by detecting inflammatory signals and activating the skin's intrinsic repair capacity.

Atopic dermatitis is characterized by immune dysregulation and barrier dysfunction. Rejuran can positively affect such damaged skin through its anti-inflammatory and regeneration-promoting properties. However, it cannot completely resolve underlying immune dysfunction.

Limitations in Atopic Dermatitis Patients

The primary concern with Rejuran in atopic patients is risk of hypersensitivity reactions. Atopic skin is inherently allergen-sensitive, and injection trauma can exacerbate inflammation.

Additionally, actively inflamed atopic skin may not show normal healing responses. Therefore, Rejuran should only be considered when atopy is adequately controlled. Before treatment, at least 4 weeks of oral therapy and topical management should normalize inflammatory markers (e.g., SCORAD).

Combining with Effective Atopy Management

In atopic dermatitis patients, Rejuran's role is adjunctive to primary treatment. First-line management includes systemic immune modulation (oral immunosuppressants, biologics), topical steroids/tacrolimus, and rigorous skincare.

Only after adequate foundational care can Rejuran be considered to promote skin regeneration in areas with chronic damage or secondary pigmentation. Primary treatments must never be discontinued after Rejuran, and recurrence risk requires monitoring.