Rejuran's Regeneration Mechanism
Rejuran (PN, Polynucleotide) is a polynucleotide complex that recognizes cellular damage signals and promotes skin regeneration. Unlike marketing claims of 'DNA repair,' it actually works by detecting inflammatory signals and activating the skin's intrinsic repair capacity.
Atopic dermatitis is characterized by immune dysregulation and barrier dysfunction. Rejuran can positively affect such damaged skin through its anti-inflammatory and regeneration-promoting properties. However, it cannot completely resolve underlying immune dysfunction.
Limitations in Atopic Dermatitis Patients
The primary concern with Rejuran in atopic patients is risk of hypersensitivity reactions. Atopic skin is inherently allergen-sensitive, and injection trauma can exacerbate inflammation.
Additionally, actively inflamed atopic skin may not show normal healing responses. Therefore, Rejuran should only be considered when atopy is adequately controlled. Before treatment, at least 4 weeks of oral therapy and topical management should normalize inflammatory markers (e.g., SCORAD).
Combining with Effective Atopy Management
In atopic dermatitis patients, Rejuran's role is adjunctive to primary treatment. First-line management includes systemic immune modulation (oral immunosuppressants, biologics), topical steroids/tacrolimus, and rigorous skincare.
Only after adequate foundational care can Rejuran be considered to promote skin regeneration in areas with chronic damage or secondary pigmentation. Primary treatments must never be discontinued after Rejuran, and recurrence risk requires monitoring.
Off-label Use and Its Place in Treatment
At present, PN intradermal injection for atopic dermatitis is an off-label use, and no large-scale randomized controlled trials (RCTs) exist yet. It is not a treatment to choose from the outset in place of standard atopic dermatitis treatments.
Its realistic place is not as a replacement for existing treatment, but as an adjunctive treatment for managing residual symptoms.
Frequently Asked Questions
- Does Rejuran actually repair DNA?
- Rejuran (PN) is not DNA fragments but a polynucleotide complex. It recognizes cellular damage signals and promotes skin regeneration. 'Regeneration promotion' is a more accurate description than 'DNA repair.'
- Can I use Rejuran if I have atopic dermatitis?
- Not recommended during active atopy. However, with adequate management to suppress inflammation, it can be cautiously considered. Precise pre-treatment assessment is essential.
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